| First Author | Raab-Graham KF | Year | 1994 |
| Journal | Neuroreport | Volume | 5 |
| Issue | 18 | Pages | 2501-5 |
| PubMed ID | 7696590 | Mgi Jnum | J:61761 |
| Mgi Id | MGI:1355562 | Doi | 10.1097/00001756-199412000-00024 |
| Citation | Raab-Graham KF, et al. (1994) Molecular cloning and expression of a human heart inward rectifier potassium channel. Neuroreport 5(18):2501-5 |
| abstractText | We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line. Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong inward rectification, blocked by extracellular Ba2+ and Cs+, and with a single-channel conductance of 30 pS. Northern analysis showed HH-IRK1 transcripts in human heart, brain, skeletal muscle, placenta, lung and kidney. HH-IRK1 was mapped to human chromosome 17. |
