| First Author | Brod SA | Year | 1995 |
| Journal | J Neuroimmunol | Volume | 58 |
| Issue | 1 | Pages | 61-9 |
| PubMed ID | 7537281 | Mgi Jnum | J:26973 |
| Mgi Id | MGI:74393 | Doi | 10.1016/0165-5728(94)00188-t |
| Citation | Brod SA, et al. (1995) Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis. J Neuroimmunol 58(1):61-9 |
| abstractText | Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAE was induced in SJL/J mice and following recovery from the initial attack, animals were fed varying doses of human or murine interferon alpha (IFN-alpha), or mock IFN three times per week. After relapse, concanavalin A-activated spleen cells were transferred adoptively from orally fed animals into recipient animals. Oral administration of human or murine IFN-alpha suppressed relapse in actively immunized animals, modified adoptive transfer of EAE, and decreased mitogen/antigen proliferation and IFN-gamma secretion in both donors and recipients. IFN-alpha acts orally by modifying the encephalitogenicity of donor spleen T cells. |
