| First Author | Lee K | Year | 1994 |
| Journal | Mamm Genome | Volume | 5 |
| Issue | 10 | Pages | 612-5 |
| PubMed ID | 7849396 | Mgi Jnum | J:21026 |
| Mgi Id | MGI:69076 | Doi | 10.1007/BF00411455 |
| Citation | Lee K, et al. (1994) Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome. Mamm Genome 5(10):612-5 |
| abstractText | The X Chromosome (Chr) genes for phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, were mapped on the mouse X Chr with interspecific backcrosses between C57BL/6 (B6) and M. spretus (S). Southern analysis showed that Prps1 mapped between Plp and DXWas31, a mouse X Chr region that is homologous to Xq21-24 on the human X Chr while Prps2 mapped between DXWas31 and Amg, a region that is homologous to the map position of PRPS2 on Xp22 of the human X Chr. Additionally, other restriction fragments highlighted by PRS II showed autosomal segregation. In situ hybridization and FISH analysis of metaphase chromosome spreads prepared from lymphocytes of B6 or S male mice confirmed that there were in fact two different locations on the X Chr, X F1-2 and X F2-3 for Prps1 and 2 respectively, as well as two autosomal sites for Prps-like genes. |
