| First Author | Goldman A | Year | 1995 |
| Journal | Medicina (B Aires) | Volume | 55 |
| Issue | 1 | Pages | 45-7 |
| PubMed ID | 7565035 | Mgi Jnum | J:26560 |
| Mgi Id | MGI:74004 | Citation | Goldman A, et al. (1995) A maternally-inherited alteration in the T cell repertoire of BALB/c mice. Medicina (B Aires) 55(1):45-7 |
| abstractText | A number of milk-borne exogenous mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. The expression of these superantigens mediate the progressive deletion of T cells expressing specific V beta products. Here we describe a maternally-inherited alteration in the T cell repertoire in one colony of BALB/c mice which has not been reported up to now. This alteration involves the deletion of V beta 2+ and 14+ CD4+ T cells and correlates with a high incidence of mammary tumors, suggesting the involvement of a superantigen(s) probably transmitted through an exogenous MMTV in milk. |
