| First Author | Sarzotti M | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5256 | Pages | 1726-8 |
| PubMed ID | 8596933 | Mgi Jnum | J:32137 |
| Mgi Id | MGI:79641 | Doi | 10.1126/science.271.5256.1726 |
| Citation | Sarzotti M, et al. (1996) Induction of protective CTL responses in newborn mice by a murine retrovirus [see comments]. Science 271(5256):1726-8 |
| abstractText | The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns. |
