| First Author | Hogarth PJ | Year | 1995 |
| Journal | Parasite Immunol | Volume | 17 |
| Issue | 12 | Pages | 653-7 |
| PubMed ID | 8834765 | Mgi Jnum | J:31698 |
| Mgi Id | MGI:79185 | Doi | 10.1111/j.1365-3024.1995.tb01011.x |
| Citation | Hogarth PJ, et al. (1995) Accelerated clearance of Onchocerca microfilariae and resistance to reinfection in interleukin-4 gene knockout mice. Parasite Immunol 17(12):653-7 |
| abstractText | Immunity to Onchocerca microfilariae (mf) in mice is associated with CD4+ Th2 cells and is dependent on IL-5. In view of the role of IL-4 in the development of Th2 cells, we have utilized IL-4 gene knockout mice (IL-4-/-) to investigate microfilarial clearance and resistance to reinfection. Paradoxically, in the absence of IL-4 there is accelerated clearance of microfilariae during a primary infection and unimpeded expression of resistance to reinfection. IL-4-/- mice showed a lack of an IgE response although peripheral eosinophilia was equivalent to wildtype controls. The data presented here suggest that elimination of mf can occur independent of IL-4 and that in this model it may even be detrimental to the host. |
