| First Author | Teitell M | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 5 | Pages | 2143-9 |
| PubMed ID | 9036959 | Mgi Jnum | J:38506 |
| Mgi Id | MGI:85889 | Doi | 10.4049/jimmunol.158.5.2143 |
| Citation | Teitell M, et al. (1997) Nonclassical behavior of the mouse CD1 class I-like molecule. J Immunol 158(5):2143-9 |
| abstractText | The mouse CD1 (mCD1) molecule is a class I-like molecule that is encoded outside of the MHC. We show here that mCD1 shares several properties with Ag-presenting class I molecules, including a requirement for beta2-microglobulin for stable cell-surface expression in T lymphocyte transfectants and thymocytes. mCD1 is also capable of binding to mouse CD8alphabeta heterodimers participating in the activation of CD8+ T cells in a manner similar to classical class I molecules. However, mCD1 surface expression is not decreased at high temperatures in cells that lack the transporter associated with Ag processing (TAP), including both RMA-S and Drosophila melanogaster cells. The data indicate that mCD1 does not require TAP to be expressed in a stable fashion at the cell surface. We speculate that the ability of mCD1 to reach the cell surface in transporter-deficient cells may reflect its ability to present a distinct set of ligands. The properties of mCD1 described here can account, in part, for the selection of the diverse populations of T cells that are known to be mCD1 reactive. |
