| First Author | Sugihara A | Year | 1996 |
| Journal | Autoimmunity | Volume | 24 |
| Issue | 4 | Pages | 237-46 |
| PubMed ID | 9147582 | Mgi Jnum | J:38037 |
| Mgi Id | MGI:85429 | Doi | 10.3109/08916939608994716 |
| Citation | Sugihara A, et al. (1996) Expression of CD45-restricted form B in (NZW x BXSB) F1 and MRL/Mp-lpr/lpr mice. Autoimmunity 24(4):237-46 |
| abstractText | Expression of CD45RB on CD4+ or CD8+ cells in combination with TCRV beta usages (V beta 6, V beta 8.1, V beta 8.2, V beta 11 and V beta 17a) in normal mouse strains (BALD/c and C57BL/6) was compared with autoimmune-prone strains (NZW x BXSB) F1 and MRL/lpr) at young and old ages. The frequencies, and also the numbers of CD45RB- cells in CD4+ T cells with various TcR repertoires was significantly less in the autoimmune-prone stains at old ages, while, in normal control strains, they remained unchanged. Furthermore, CD4+/CD45RB- cells are CD44high and CD62L (L- selectin).low These findings suggest that most T cells, especially CD4+ T cells, in old W/BF1 and old MRL/lpr mice, were activated and this may reflect the elevation of autoantibodies and the progress of autoimmune status in aged autoimmune-prone mice. This will be discussed in relation to the progress of the autoimmune diseases. |
