| First Author | Mittal V | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5303 | Pages | 1136-40 |
| PubMed ID | 9027316 | Mgi Jnum | J:38692 |
| Mgi Id | MGI:86074 | Doi | 10.1126/science.275.5303.1136 |
| Citation | Mittal V, et al. (1997) Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science 275(5303):1136-40 |
| abstractText | Basal transcription from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc). TBP consists of a conserved carboxyl-terminal domain that performs all known functions of the protein and a nonconserved amino-terminal region of unknown function. Here, the amino-terminal region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAPc to the U6 promoter, and enhance U6 transcription. |
