| First Author | Kossodo S | Year | 1997 |
| Journal | Immunology | Volume | 91 |
| Issue | 4 | Pages | 536-40 |
| PubMed ID | 9378491 | Mgi Jnum | J:42151 |
| Mgi Id | MGI:1095237 | Doi | 10.1046/j.1365-2567.1997.00290.x |
| Citation | Kossodo S, et al. (1997) Interleukin-10 modulates susceptibility in experimental cerebral malaria. Immunology 91(4):536-40 |
| abstractText | In this study, we examined the effects of interleukin-10 (IL-10) on the outcome of experimental cerebral malaria (CM), a lethal neurological syndrome that occurs in susceptible strains of mice after infection with Plasmodium berghei ANKA (PbA). Constitutive IL-10 mRNA levels were significantly higher in the spleen and brain of resistant animals. In vivo neutralization of endogenous IL-10 in CM-resistant mice induced the neurological syndrome in 35.7% of these mice, as opposed to 7.7% in controls. IL-10 inhibited PbA antigen-specific interferon-gamma (IFN-gamma) production in vitro but not tumour necrosis factor (TNF) serum levels in vivo. Susceptible mice, on the other hand, were significantly protected against CM when injected with recombinant IL-10. Overall, our findings suggest that IL-10 plays a protective role against experimental cerebral malaria. |
