| First Author | Mishra L | Year | 1998 |
| Journal | Int J Dev Biol | Volume | 42 |
| Issue | 2 | Pages | 221-4 |
| PubMed ID | 9551868 | Mgi Jnum | J:46477 |
| Mgi Id | MGI:1201224 | Citation | Mishra L, et al. (1998) Identification of elf1, a beta-spectrin, in early mouse liver development. Int J Dev Biol 42(2):221-4 |
| abstractText | Beta-spectrins play essential roles in cell-cell interactions and in the maintenance of cell polarity. Our aim was to identify beta-spectrin genes important for the establishment of hepatocyte polarity and differentiation. Using subtractive screening of cDNA libraries from early embryonic mouse livers (post-coital days 10, 11, and 12), we have isolated elf1 (embryonic liver fodrin 1), a differentially expressed beta-spectrin or fodrin (betaSpIIsigmaI). Elf1 encodes a 220-amino acid protein with an NH2 terminal actin-binding domain. In situ hybridization studies demonstrate elf1 expression initially in day 10 embryonic heart tissue, then in day 11-11.5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development. |
