| First Author | al-Fahim A | Year | 1998 |
| Journal | Immunol Cell Biol | Volume | 76 |
| Issue | 1 | Pages | 27-33 |
| PubMed ID | 9553773 | Mgi Jnum | J:46888 |
| Mgi Id | MGI:1202198 | Doi | 10.1046/j.1440-1711.1998.00711.x |
| Citation | al-Fahim A, et al. (1998) Second symmetry in the BALB/c-C57BL/6 (B6) system, and anti-antiself antibodies in ageing B6 mice. Immunol Cell Biol 76(1):27-33 |
| abstractText | Using an ELISA assay and inhibition of antibody mediated cytotoxicity we found that there was a higher level of anti-antiself activity in B6 anti-BALB/c alloimmune mice than in BALB/c anti-B6 mice. In contrast, when an inhibition of cellular cytotoxicity assay was used to assay for the activity, similar levels of anti-antiself antibodies were seen in B6 anti-BALB/c and BALB/c anti-B6 sera. Anti-antiself antibodies in alloimmune sera are not absorbed by the cellular immunogen as readily as are anti-foreign antibodies. These results are interpreted in terms of anti-antiself antibodies being directed mainly against T cell receptors specific for self. Anti-antiself antibodies are found also in old B6 mice, that are also known to make autoantibodies. |
