| First Author | Gao ZG | Year | 1998 |
| Journal | Pharmacol Res | Volume | 38 |
| Issue | 2 | Pages | 101-6 |
| PubMed ID | 9721596 | Mgi Jnum | J:49537 |
| Mgi Id | MGI:1277642 | Doi | 10.1006/phrs.1998.0337 |
| Citation | Gao ZG, et al. (1998) Effects of nicotine on 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced depression of striatal dopamine content and spontaneous locomotor activity in C57 black mice. Pharmacol Res 38(2):101-6 |
| abstractText | The present study examined the effects of nicotine on the levels of dopamine and its metabo- lite 3,4-dihydroxy-phenylacetic acid (DOPAC) in the striatum and on spontaneous locomotor activity of C57 black mice that had been treated with the neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydro-pyridine (MPTP). The levels of dopamine and DOPAC in the striatum were significantly reduced 10 days after two injections of MPTP (40 mg kg-1, i.p., 24 h apart) in mice. Chronic treatment of nicotine (2.0 mg kg-1, s.c., four injections per day) did not influence the striatal content of dopamine and DOPAC, but it significantly antagonised MPTP-induced depression of dopamine. However, the chronic nicotine treatment did not significantly affect MPTP-induced depression of DOPAC. It was demonstrated that the lethal effect of MPTP was also partly protected by the chronic nicotine treat-ment. The chronic nicotine treatment also significantly protected MPTP-depressed spontaneous locomotor activity in mice. The results suggest that both MPTP-depressed behaviour and MPTP-induced striatal dopamine depletion in C57 black mice are partly protected by chronic nicotine treatment. |
