| First Author | Johnston CM | Year | 1998 |
| Journal | Cell | Volume | 94 |
| Issue | 6 | Pages | 809-17 |
| PubMed ID | 9753327 | Mgi Jnum | J:49849 |
| Mgi Id | MGI:1289126 | Doi | 10.1016/s0092-8674(00)81739-0 |
| Citation | Johnston CM, et al. (1998) Developmentally regulated Xist promoter switch mediates initiation of X inactivation. Cell 94(6):809-17 |
| abstractText | Developmental regulation of the mouse Xist gene at the onset of X chromosome inactivation is mediated by RNA stabilization. Here, we show that alternate promoter usage gives rise to distinct stable and unstable RNA isoforms. Unstable Xist transcript initiates at a novel upstream promoter, whereas stable Xist RNA is transcribed from the previously identified promoter and from a novel downstream promoter. Analysis of cells undergoing X inactivation indicates that a developmentally regulated promoter switch mediates stabilization and accumulation of Xist RNA on the inactive X chromosome. |
