First Author | Degermann S | Year | 1999 |
Journal | J Exp Med | Volume | 189 |
Issue | 10 | Pages | 1679-84 |
PubMed ID | 10330447 | Mgi Jnum | J:55052 |
Mgi Id | MGI:1337183 | Doi | 10.1084/jem.189.10.1679 |
Citation | Degermann S, et al. (1999) T cell receptor beta chain lacking the large solvent-exposed Cbeta FG loop supports normal alpha/beta T cell development and function in transgenic mice. J Exp Med 189(10):1679-84 |
abstractText | The striking and unique structural feature of the T cell receptor (TCR) beta chain is the bulky solvent-exposed FG loop on the Cbeta domain, the size of almost half an immunoglobulin domain. The location and size of this loop suggested immediately that it could be a crucial structural link between the invariant CD3 subunits and antigen-recognizing alpha/beta chains during TCR signaling. However, functional analysis does not support the above notion, since transgene coding for TCR beta chain lacking the complete FG loop supports normal alpha/beta T cell development and function. |