| First Author | Shu T | Year | 2003 |
| Journal | Development | Volume | 130 |
| Issue | 13 | Pages | 2929-37 |
| PubMed ID | 12756176 | Mgi Jnum | J:83531 |
| Mgi Id | MGI:2662557 | Doi | 10.1242/dev.00514 |
| Citation | Shu T, et al. (2003) The glial sling is a migratory population of developing neurons. Development 130(13):2929-37 |
| abstractText | For two decades the glial sling has been hypothesized to act as a guidance substratum for developing callosal axons. However, neither the cellular nature of the sling nor its guidance properties have ever been clearly identified. Although originally thought to be glioblasts, we show here that the subventricular zone cells forming the sling are in fact neurons. Sling cells label with a number of neuronal markers and display electrophysiological properties characteristic of neurons and not glia. Furthermore, sling cells are continuously generated until early postnatal stages and do not appear to undergo widespread cell death. These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance. |
