| Type | MGI:General | Description | occasionally, rare deaths occur during ultrasound handling of mutants, indicating increased susceptibility to adrenergic stress adrenergic stimulation of mutants with isoproterenol induces increased incidence of cardiac arrhythmias (decreased R wave amplitude, widened QRS complex, complex arrhythmias) and sudden death in 100% of mutants compared to wild-type mice which show increased heart rate but do not die and return to normal |
