mice are susceptible to infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) strain hCoV-EMC , showing up to 28% weight loss by 5 days post infection (dpi), significant viral titers in the lungs and in the brain, and severe lung disease related to acute respiratory symptoms mice are also susceptible to infection with high-titer of an optimized pseudotyped MERS-CoV, with younger mice more susceptible than older mice
