| Type | MGI:General | Description | mice develop dense and irregular myofibrillar aggregates in the quadriceps, triceps, and the extensor digitorum longus (EDL) muscles myofibrillar aggregates are often associated with autophagic vesicles the aggregations are progressive with age starting at 2 weeks when small focal points of aggregation are detectable aggregates expand up to 40 micrometers and will often occupy the entire cross-sectional area of the myofibers of older mice the proportion of myofibers containing aggregates is 11-12% at 6 months and 17-18.2% at 12 months of age |
