| Type | MGI:General | Description | mice exhibit a spectrum of urothelial neoplasia ranging from dysplasia to muscle-invasive urothelial carcinoma that resembles human urothelial carcinomas 14% of mice develop only low-grade noninvasive tumors 29% of mice develop either invasive carcinoma or carcinoma-in-situ all invasive tumors show muscle invasion and muscle-invasive tumors consist of malignant cells infiltrating into the muscularis papillary carcinomas are multifocal with fibrovascular stalks projecting into the bladder lumen PTEN protein expression is lost in both noninvasive and muscle-invasive bladder cancers |
