| Type | MGI:General | Description | proportion of myocyte nuclei with tubulo-filamentous ultrastructures and containing KCl-insoluble aggregates increases with age, compared to nontransgenic controls mutants have increased numbers of apoptotic myocyte nuclei compared to controls at 6-12 months musle has increased numbers vacuoules aggregate formation is decreased with DOX treatment and number of apoptotic nuclei is reduced |