a subset of mice infected intranasally with SARS-CoV-2 show decreased body weight from days 4 to 6 post-infection, show noticeable respiratory distress and neurological symptoms viral RNA is detected in all lungs from 1 dpi with SARS-CoV-2 and increases slowly until 5 dpi and then decreases beginning 7 dpi; low levels of viral RNA is seen in the eyes and hearts of some of the mice viral antigens are seen in the bronchial epithelial cells and alveolar cells of the lungs deceased mice show viral antigens in the brain levels of neutrophils and monocytes begin to increase in the peripheral blood at day 1 of SARS-CoV-2 infection, peak at day 3, and decrease at 5-7 days post-infection (dpi)
