| First Author | Evsikov AV | Year | 2004 |
| Journal | Cytogenet Genome Res | Volume | 105 |
| Issue | 2-4 | Pages | 240-50 |
| PubMed ID | 15237213 | Mgi Jnum | J:91422 |
| Mgi Id | MGI:3047029 | Doi | 10.1159/000078195 |
| Citation | Evsikov AV, et al. (2004) Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res 105(2-4):240-50 |
| abstractText | The transcriptome of the 2-cell mouse embryo was analyzed to provide insight into the molecular networks at play during nuclear reprogramming and embryonic genome activation. Analysis of ESTs from a 2-cell cDNA library identified nearly 4,000 genes, over half of which have not been previously studied. Transcripts of mobile elements, especially those of LTR retrotransposons, are abundantly represented in 2-cell embryos, suggesting their possible role in introducing genomic variation, and epigenetic restructuring of the embryonic genome. Analysis of Gene Ontology of the 2-cell-stage expressed genes outlines the major biological processes that guide the oocyte-to-embryo transition. These results provide a foundation for understanding molecular control at the onset of mammalian development. |
