| First Author | Gérard A | Year | 2004 |
| Journal | Oncogene | Volume | 23 |
| Issue | 8 | Pages | 1594-8 |
| PubMed ID | 14647425 | Mgi Jnum | J:88384 |
| Mgi Id | MGI:3032900 | Doi | 10.1038/sj.onc.1207283 |
| Citation | Gerard A, et al. (2004) Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. Oncogene 23(8):1594-8 |
| abstractText | The Dok adaptor family of proteins binding to RasGAP, consisting of Dok-1 and Dok-2, are critical regulators in cell proliferation. These molecules are partners and/or substrates of different protein tyrosine kinases considered as oncoproteins. Here, we show that Dok-1 and Dok-2 are the major tyrosine-phosphorylated proteins associated to Tec, a protein tyrosine kinase expressed in T cells. Furthermore, we evaluate the effect of Dok-1 or Dok-2 on Tec-mediated signalling pathways in T cells. Here, we provide evidence that Dok-1 and Dok-2 proteins are involved in a negative feedback regulation of Tec via a downregulation of its tyrosine phosphorylation and downstream signalling pathways including the Ras pathway. Either Dok-1 or Dok-2 therefore represents a mean of potent retrograde control for protein tyrosine kinase signalling, and then possibly of tumor development. |
