| First Author | Ito C | Year | 2004 |
| Journal | Planta Med | Volume | 70 |
| Issue | 6 | Pages | 585-8 |
| PubMed ID | 15229812 | Mgi Jnum | J:91627 |
| Mgi Id | MGI:3047750 | Doi | 10.1055/s-2004-815447 |
| Citation | Ito C, et al. (2004) Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata. Planta Med 70(6):585-8 |
| abstractText | A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters. |
