| First Author | Kaltschmidt B | Year | 2005 |
| Journal | Biochim Biophys Acta | Volume | 1745 |
| Issue | 3 | Pages | 287-99 |
| PubMed ID | 15993497 | Mgi Jnum | J:101917 |
| Mgi Id | MGI:3605921 | Doi | 10.1016/j.bbamcr.2005.05.009 |
| Citation | Kaltschmidt B, et al. (2005) Signaling via NF-kappaB in the nervous system. Biochim Biophys Acta 1745(3):287-99 |
| abstractText | Nuclear factor kappa B (NF-kappaB) is an inducible transcription factor present in neurons and glia. Recent genetic models identified a role for NF-kappaB in neuroprotection against various neurotoxins. Furthermore, genetic evidence for a role in learning and memory is now emerging. This review highlights our current understanding of neuronal NF-kappaB in response to synaptic transmission and summarizes potential physiological functions of NF-kappaB in the nervous system. This article contains a listing of NF-kappaB activators and inhibitors in the nervous system, furthermore specific target genes are discussed. Synaptic NF-kappaB activated by glutamate and Ca2+ will be presented in the context of retrograde signaling. A controversial role of NF-kappaB in neurodegenerative diseases will be discussed. A model is proposed explaining this paradox as deregulated physiological NF-kappaB activity, where novel results are integrated, showing that p65 could be turned from an activator to a repressor of anti-apoptotic genes. |
