| First Author | Thimme R | Year | 2005 |
| Journal | J Virol | Volume | 79 |
| Issue | 18 | Pages | 12112-6 |
| PubMed ID | 16140789 | Mgi Jnum | J:101768 |
| Mgi Id | MGI:3605171 | Doi | 10.1128/JVI.79.18.12112-12116.2005 |
| Citation | Thimme R, et al. (2005) Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol 79(18):12112-6 |
| abstractText | The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation. |
