| First Author | Veinbergs I | Year | 1999 |
| Journal | Neurosci Lett | Volume | 265 |
| Issue | 3 | Pages | 218-22 |
| PubMed ID | 10327170 | Mgi Jnum | J:108020 |
| Mgi Id | MGI:3622861 | Doi | 10.1016/s0304-3940(99)00243-8 |
| Citation | Veinbergs I, et al. (1999) Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. Neurosci Lett 265(3):218-22 |
| abstractText | The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein-E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showed dendritic alterations in pyramidal neurons of apolipoprotein-E4 transgenic mice, similar to the ones observed in apolipoprotein E-deficient mice. However, these mice had a preserved density of synaptophysin-immunoreactive presynaptic terminals. In contrast, mice overexpressing apolipoprotein-E3 showed no synapto-dendritic alterations. Analysis of behavioral performance in the Morris water maze showed that while apolipoprotein E-deficient mice performed poorly, overexpression of apolipoprotein-E3 and, to a lower extent apolipoprotein-E4, resulted in an improved performance. This study supports the contention that, compared with apolipoprotein-E4, apolipoprotein-E3 might have a greater neurotrophic in vivo effect in aged mice. |
