| First Author | Franco-Pons N | Year | 2006 |
| Journal | Neuroscience | Volume | 140 |
| Issue | 2 | Pages | 463-75 |
| PubMed ID | 16603319 | Mgi Jnum | J:108866 |
| Mgi Id | MGI:3625215 | Doi | 10.1016/j.neuroscience.2006.02.033 |
| Citation | Franco-Pons N, et al. (2006) Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination. Neuroscience 140(2):463-475 |
| abstractText | Discoidin domain receptor 1 is a tyrosine kinase receptor expressed in a variety of tissues including the brain. This study describes mRNA and protein expression of discoidin domain receptor 1 in mouse brain during development and provides new insights into its role during gliogenesis and neurogenesis. We performed in situ hybridization for discoidin domain receptor 1 in mouse brains at embryonic day 18, postnatal days 5, 9, 15, 21 and adulthood and observed a diffuse pattern in the proliferative areas during embryogenesis. From postnatal day 5 onwards, a defined cellular expression pattern of discoidin domain receptor 1 was observed, mainly located in white matter tracts and following a spatio-temporal pattern that overlapped the progress of myelination. Next, we performed double-labeling reactions (in situ hybridization followed by immunohistochemistry) that confirmed that discoidin domain receptor 1 was expressed by mature oligodendrocytes. We observed that cells positive for discoidin domain receptor 1 also expressed carnosine and anti-adenomatous polyposis coli, two mature oligodendrocyte markers. Based on the localization of discoidin domain receptor 1 specifically in the white matter fiber tracts during postnatal development, we suggest that discoidin domain receptor 1 participates in the development and maintenance of the myelin sheath. |
