| First Author | Dar A | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 10 | Pages | 1038-46 |
| PubMed ID | 16170318 | Mgi Jnum | J:110191 |
| Mgi Id | MGI:3639614 | Doi | 10.1038/ni1251 |
| Citation | Dar A, et al. (2005) Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol 6(10):1038-46 |
| abstractText | Regulation of the availability of chemokine SDF-1 (CXCL12) in bone marrow is still not fully understood. Here we describe a unique function for the chemokine receptor CXCR4 expressed on bone marrow endothelial cells, which efficiently internalize circulating SDF-1, resulting in its translocation into the bone marrow. Translocated SDF-1 increased the homing of transplanted human CD34(+) hematopoietic progenitors to the bone marrow. The chemokine transporter function of CXCR4 was a characteristic of endothelial and stromal cells but not of hematopoietic cells. Thus, chemokine translocation across the blood-bone marrow barrier allows effective transfer of functional SDF-1 from the periphery to the stem cell niche in the bone marrow during both homeostasis and 'alarm' situations. |
