| First Author | Shirota H | Year | 2006 |
| Journal | Immunology | Volume | 118 |
| Issue | 3 | Pages | 302-10 |
| PubMed ID | 16827891 | Mgi Jnum | J:111933 |
| Mgi Id | MGI:3655175 | Doi | 10.1111/j.1365-2567.2006.02367.x |
| Citation | Shirota H, et al. (2006) Contribution of interferon-beta to the immune activation induced by double-stranded DNA. Immunology 118(3):302-10 |
| abstractText | Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-beta (IFN-beta) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN-beta) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA. |
