| First Author | Duarte M | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 350 |
| Issue | 3 | Pages | 604-9 |
| PubMed ID | 17027650 | Mgi Jnum | J:114977 |
| Mgi Id | MGI:3690497 | Doi | 10.1016/j.bbrc.2006.09.107 |
| Citation | Duarte M, et al. (2006) Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochem Biophys Res Commun 350(3):604-9 |
| abstractText | Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis. |
