| First Author | Kim H | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5828 | Pages | 1202-5 |
| PubMed ID | 17525342 | Mgi Jnum | J:121845 |
| Mgi Id | MGI:3712395 | Doi | 10.1126/science.1139621 |
| Citation | Kim H, et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316(5828):1202-5 |
| abstractText | Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically recruits BRCA1 to DNA damage sites and functions with BRCA1 in G2/M checkpoint control. Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response. |
