| First Author | Anton R | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 27 | Pages | 5247-54 |
| PubMed ID | 17950287 | Mgi Jnum | J:127751 |
| Mgi Id | MGI:3764774 | Doi | 10.1016/j.febslet.2007.10.012 |
| Citation | Anton R, et al. (2007) Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS Lett 581(27):5247-54 |
| abstractText | ES cells can self-renew while preserving pluripotency and are able to differentiate into many cell types. In both processes, different signal transduction pathways are implicated, including the Wnt/beta-catenin pathway, which we here further analyzed. We found that a loss of beta-catenin in ES cells leads to altered expression of stem cell marker genes. TCF/beta-catenin reporter gene assays indicate that undifferentiated murine ES cells are capable of reacting to LiCl and Wnt3a but not Wnt5a stimulation, but have low endogenous TCF/beta-catenin activity. Oct-3/4, nanog and Wnt11 were able to repress TCF/beta-catenin transcriptional activity. During differentiation, activation of the Wnt/beta-catenin pathway influences formation of mesoderm and cardiomyocytes in a time and dose dependent manner. |
