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Publication : Autosomal aneuploidy in mice: generation and developmental consequences.

First Author  Gearhart JD Year  1986
Journal  Brain Res Bull Volume  16
Issue  6 Pages  789-801
PubMed ID  3530382 Mgi Jnum  J:133942
Mgi Id  MGI:3784672 Doi  10.1016/0361-9230(86)90075-4
Citation  Gearhart JD, et al. (1986) Autosomal aneuploidy in mice: generation and developmental consequences. Brain Res Bull 16(6):789-801
abstractText  Spontaneous aneuploidy in the mouse is uncommon, but specific mating schemes have been developed that produce aneuploid conceptuses at high frequencies. The most commonly reported aneuploid condition in the mouse is autosomal trisomy, in which there is an extra copy (in whole or in part) of a chromosome. In this review, we present several of the schemes used in producing trisomic, partially (tertiary) trisomic, and monosomic conceptuses and summarize the developmental consequences that are associated with each of the autosomal trisomies of the mouse.
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