| First Author | Xu C | Year | 2008 |
| Journal | Gene Expr Patterns | Volume | 8 |
| Issue | 7-8 | Pages | 502-7 |
| PubMed ID | 18617019 | Mgi Jnum | J:138310 |
| Mgi Id | MGI:3804773 | Doi | 10.1016/j.gep.2008.06.003 |
| Citation | Xu C, et al. (2008) Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. Gene Expr Patterns 8(7-8):502-7 |
| abstractText | The hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) contain neuroendocrine cells that modulate pituitary secretion to maintain homeostasis. These two nuclei have a common developmental origin but they eventually form at locations distant from each other. Little is known about the molecular cues that direct the segregation of PVN and SON. As a means to identify potential factors, we have documented expression patterns of genes with known guidance roles in neural migration. Here, we focus on two groups of ligand/receptor families classified to mediate chemo-repulsion of neurons and their axons: the Slit/Robo and the Semaphorin/Plexin/Neuropilin families. Their dynamic expression patterns within and around the common PVN/SON progenitor as well as the mature PVN and SON may provide a framework for understanding the formation of these two important nuclei. |
