| First Author | Wang Y | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 8 | Pages | 1503-8 |
| PubMed ID | 20206170 | Mgi Jnum | J:159332 |
| Mgi Id | MGI:4442305 | Doi | 10.1016/j.febslet.2010.02.069 |
| Citation | Wang Y, et al. (2010) Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells. FEBS Lett 584(8):1503-8 |
| abstractText | Ghrelin inhibits insulin secretion partly via induction of IA-2beta. However, the orexigenic effect of ghrelin is mediated by the AMP-activated protein kinase (AMPK)-uncoupling protein 2 (UCP2) pathway. Here, we demonstrate that ghrelin's inhibitory effect on insulin secretion also occurs through the AMPK-UCP2 pathway. Ghrelin increased AMPK phosphorylation and UCP2 mRNA expression in MIN6 insulinoma cells. Overexpression or downregulation of UCP2 attenuated or enhanced insulin secretion, respectively. Furthermore, AMPK activator had a similar effect to ghrelin on UCP2 and insulin secretion in MIN6 cells. In conclusion, ghrelin's inhibitory effect on insulin secretion is partly mediated by the AMPK-UCP2 pathway, which is independent of the IA-2beta pathway. |
