| First Author | Suto J | Year | 2011 |
| Journal | Mamm Genome | Volume | 22 |
| Issue | 11-12 | Pages | 648-60 |
| PubMed ID | 21858720 | Mgi Jnum | J:176248 |
| Mgi Id | MGI:5289754 | Doi | 10.1007/s00335-011-9353-3 |
| Citation | Suto J (2011) Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains. Mamm Genome 22(11-12):648-60 |
| abstractText | In the present study, dissection of genetic bases of testis weight in mice was performed. Autosomes and the X chromosome were searched using traditional quantitative trait locus (QTL) scans, and the Y chromosome was searched by association studies of Y-consomic strains. QTL analysis was performed in female symbolDDD x male symbolCBA F(2) mice; the inbred mouse DDD has the heaviest testes, whereas the inbred mouse CBA has the lightest testes. Two significant testis weight QTLs were identified on chromosomes 1 and X. A DDD allele was associated with increased and decreased testis weight at the locus on chromosomes 1 and X, respectively. In the reciprocal cross female symbolCBA x male symbolDDD F(2) mice, QTL on chromosome 1, and not on chromosome X, had a significant effect on testis weight. The DDD allele at the X-linked locus could not sustain testis weight in combination with the Y chromosome of the CBA strain. The Y chromosome per se had a significant effect on testis weight, i.e., DH-Chr Y(DDD) had significantly heavier testes than DH-Chr Y(CBA). On the basis of the results of Y-chromosome-wide association studies using 17 Y-consomic strains, variations in Uty, Usp9y, and Sry were significantly associated with testis weight. Thus, testis weight is a complex quantitative phenotype controlled by multiple genes on autosomes and sex chromosomes and their interactions. |
