| First Author | Bikkavilli RK | Year | 2012 |
| Journal | J Cell Sci | Volume | 125 |
| Issue | Pt 10 | Pages | 2446-56 |
| PubMed ID | 22357953 | Mgi Jnum | J:197712 |
| Mgi Id | MGI:5494366 | Doi | 10.1242/jcs.100933 |
| Citation | Bikkavilli RK, et al. (2012) Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2. J Cell Sci 125(Pt 10):2446-56 |
| abstractText | Wnt signaling is initiated upon binding of Wnt proteins to Frizzled proteins and their co-receptors LRP5 and 6. The signal is then propagated to several downstream effectors, mediated by the phosphoprotein scaffold, dishevelled. We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation. G3BP2, a dishevelled-associated protein, is methylated in response to Wnt3a. The Wnt3a-induced LRP6 phosphorylation is attenuated by G3BP2 knockdown, chemical inhibition of methyl transferase activity or expression of methylation-deficient mutants of G3BP2. Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive 'switch' regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling. |
