| First Author | Wang N | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 18 | Pages | 3032-7 |
| PubMed ID | 23892074 | Mgi Jnum | J:200925 |
| Mgi Id | MGI:5510276 | Doi | 10.1016/j.febslet.2013.07.033 |
| Citation | Wang N, et al. (2013) LMO4 modulates proliferation and differentiation of 3T3-L1 preadipocytes. FEBS Lett 587(18):3032-7 |
| abstractText | Previous microarray analyses revealed that LMO4 is expressed in 3T3-L1 preadipocytes, however, its roles in adipogenesis are unknown. In the present study, using RT-PCR sequencing and quantitative real-time RT-PCR, we confirmed that LMO4 gene is expressed in 3T3-L1 preadipocytes and its expression peaks at the early stage of 3T3-L1 preadipocyte differentiation. Further analyses showed that LMO4 knockdown decreased the proliferation of 3T3-L1 preadipocytes, and attenuated the differentiation of 3T3-L1 preadipocytes, as evidenced by reduced lipid accumulation and down-regulation of PPARgamma gene expression. Collectively, our findings indicate that LMO4 is a novel modulator of adipogenesis. |
