| First Author | Wang Y | Year | 2013 |
| Journal | Diabetes | Volume | 62 |
| Issue | 3 | Pages | 887-95 |
| PubMed ID | 23223022 | Mgi Jnum | J:208593 |
| Mgi Id | MGI:5563743 | Doi | 10.2337/db12-0451 |
| Citation | Wang Y, et al. (2013) MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells. Diabetes 62(3):887-95 |
| abstractText | Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic beta-cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the microRNA (miR)-7/7ab family member miR-7a is enriched in mouse adult pancreatic islets compared with miR-7b. Remarkably, miR-7a targets five components of the mTOR signaling pathway. Further, inhibition of miR-7a activates mTOR signaling and promotes adult beta-cell replication in mouse primary islets, which can be reversed by the treatment with a well-known mTOR inhibitor, rapamycin. These data suggest that miR-7 acts as a brake on adult beta-cell proliferation. Most importantly, this miR-7-mTOR proliferation axis is conserved in primary human beta-cells, implicating miR-7 as a therapeutic target for diabetes. |
