First Author | Vonderheide RH | Year | 2014 |
Journal | Cancer Cell | Volume | 25 |
Issue | 5 | Pages | 553-4 |
PubMed ID | 24823632 | Mgi Jnum | J:210594 |
Mgi Id | MGI:5571508 | Doi | 10.1016/j.ccr.2014.04.020 |
Citation | Vonderheide RH (2014) Tumor-promoting inflammatory networks in pancreatic neoplasia: another reason to loathe Kras. Cancer Cell 25(5):553-4 |
abstractText | Oncogenic Kras is increasingly appreciated as an instigator of an inflammatory program that facilitates pancreatic cancer. In this issue of Cancer Cell, McAllister and colleagues use both gain-of-function and loss-of-function studies to demonstrate that oncogenic Kras activates an IL-17-dependent pathway that promotes the initiation and progression of preinvasive pancreatic neoplasia. |