| First Author | García-Negredo G | Year | 2014 |
| Journal | J Neurosci | Volume | 34 |
| Issue | 44 | Pages | 14793-802 |
| PubMed ID | 25355231 | Mgi Jnum | J:217422 |
| Mgi Id | MGI:5613869 | Doi | 10.1523/JNEUROSCI.2038-14.2014 |
| Citation | Garcia-Negredo G, et al. (2014) Coassembly and coupling of SK2 channels and mGlu5 receptors. J Neurosci 34(44):14793-802 |
| abstractText | Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly. |
