| First Author | Cantó C | Year | 2015 |
| Journal | Cell Metab | Volume | 22 |
| Issue | 1 | Pages | 31-53 |
| PubMed ID | 26118927 | Mgi Jnum | J:226111 |
| Mgi Id | MGI:5695801 | Doi | 10.1016/j.cmet.2015.05.023 |
| Citation | Canto C, et al. (2015) NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab 22(1):31-53 |
| abstractText | NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited. |
