First Author | De Miguel C | Year | 2015 |
Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 309 |
Issue | 9 | Pages | R1071-3 |
PubMed ID | 25994955 | Mgi Jnum | J:230615 |
Mgi Id | MGI:5763357 | Doi | 10.1152/ajpregu.00142.2015 |
Citation | De Miguel C, et al. (2015) Endothelium-derived ET-1 and the development of renal injury. Am J Physiol Regul Integr Comp Physiol 309(9):R1071-3 |
abstractText | The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner. |