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Publication : Endothelium-derived ET-1 and the development of renal injury.

First Author  De Miguel C Year  2015
Journal  Am J Physiol Regul Integr Comp Physiol Volume  309
Issue  9 Pages  R1071-3
PubMed ID  25994955 Mgi Jnum  J:230615
Mgi Id  MGI:5763357 Doi  10.1152/ajpregu.00142.2015
Citation  De Miguel C, et al. (2015) Endothelium-derived ET-1 and the development of renal injury. Am J Physiol Regul Integr Comp Physiol 309(9):R1071-3
abstractText  The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.
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