| First Author | Tamori Y | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 6 | Pages | 750-9 |
| PubMed ID | 26921608 | Mgi Jnum | J:231678 |
| Mgi Id | MGI:5774592 | Doi | 10.1002/1873-3468.12114 |
| Citation | Tamori Y, et al. (2016) Negatively-charged residues in the polar carboxy-terminal region in FSP27 are indispensable for expanding lipid droplets. FEBS Lett 590(6):750-9 |
| abstractText | FSP27 has an important role in large lipid droplet (LD) formation because it exchanges lipids at the contact site between LDs. In the present study, we clarify that the amino-terminal domain of FSP27 (amino acids 1-130) is dispensable for LD enlargement, although it accelerates LD growth. LD expansion depends on the carboxy-terminal domain of FSP27 (amino acids 131-239). Especially, the negative charge of the acidic residues (D215, E218, E219 and E220) in the polar carboxy-terminal region (amino acids 202-239) is essential for the enlargement of LD. We propose that the carboxy-terminal domain of FSP27 has a crucial role in LD expansion, whereas the amino-terminal domain only has a supportive role. |
