| First Author | Lin Q | Year | 2017 |
| Journal | Proc Natl Acad Sci U S A | Volume | 114 |
| Issue | 34 | Pages | 9188-9193 |
| PubMed ID | 28790189 | Mgi Jnum | J:244564 |
| Mgi Id | MGI:5913343 | Doi | 10.1073/pnas.1706069114 |
| Citation | Lin Q, et al. (2017) MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proc Natl Acad Sci U S A 114(34):9188-9193 |
| abstractText | The prenatal period of cortical development is important for the establishment of neural circuitry and functional connectivity of the brain; however, the molecular mechanisms underlying this process remain unclear. Here we report that disruption of the actin-cytoskeletal network in the developing mouse prefrontal cortex alters dendritic morphogenesis and synapse formation, leading to enhanced formation of fear-related memory in adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative regulation of diaphanous homologous protein 1 (Diap1), a key organizer of the actin cytoskeletal assembly. Our findings not only revealed important regulation of dendritogenesis and synaptogenesis during early brain development but also demonstrated a tight link between these early developmental events and cognitive functions later in life. |
