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Publication : Molecular aspects of sex determination in mice: an alternative model for the origin of the Sxr region.

First Author  Bishop CE Year  1988
Journal  Philos Trans R Soc Lond B Biol Sci Volume  322
Issue  1208 Pages  119-24
PubMed ID  2907795 Mgi Jnum  J:34256
Mgi Id  MGI:81721 Doi  10.1098/rstb.1988.0119
Citation  Bishop CE, et al. (1988) Molecular aspects of sex determination in mice: an alternative model for the origin of the Sxr region. Philos Trans R Soc Lond B Biol Sci 322(1208):119-24
abstractText  Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling primary sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region and propose an alternative model for the generation of the original Sxr region.
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