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Publication : Sex differences in the effects of acute swim stress on binding to GABAA receptors in mouse brain.

First Author  Akinci MK Year  1993
Journal  J Neurochem Volume  60
Issue  6 Pages  2212-6
PubMed ID  8388035 Mgi Jnum  J:12698
Mgi Id  MGI:60932 Doi  10.1111/j.1471-4159.1993.tb03507.x
Citation  Akinci MK, et al. (1993) Sex differences in the effects of acute swim stress on binding to GABAA receptors in mouse brain. J Neurochem 60(6):2212-6
abstractText  Acute swim stress (3-min swim at 32 degrees C) in female, but not in male, mice results in substantial changes in the characteristics of GABA binding to membranes prepared from the forebrain. These changes were larger when measured in a relatively crude membrane preparation than in a well-washed membrane preparation commonly used in GABA binding assays, consistent with the loss of endogenous modulators of GABA binding in the latter preparation. These changes may be related to stress-induced alterations in part in the modulation of the characteristics of GABA binding by endogenous steroids, as the acute swim stress produced a larger increase in plasma corticosterone levels in female than in male mice.
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