| First Author | Tarutani S | Year | 1993 |
| Journal | Microbiol Immunol | Volume | 37 |
| Issue | 2 | Pages | 135-42 |
| PubMed ID | 7684808 | Mgi Jnum | J:22003 |
| Mgi Id | MGI:66524 | Doi | 10.1111/j.1348-0421.1993.tb03190.x |
| Citation | Tarutani S (1993) Collagen-induced arthritis suppressed with monoclonal anti-idiotypic antibody. Microbiol Immunol 37(2):135-42 |
| abstractText | In foregoing work, we identified at least 5 distinct epitopes on human type II collagen (CII), using 8 murine monoclonal antibodies (mAb) against human CII, and suggested that a species-nonspecific epitope on CII recognized by anti-CII mAb termed 1-5 is an arthritogenic epitope. We also found that antibody response against a selected epitope of human CII could be induced by immunization with rabbit anti-idiotypic (Id) antibody against anti-CII mAb. The author developed and characterized monoclonal anti-Id antibodies against 1-5 mAb recognizing a putative arthritogenic epitope. The author also investigated whether the anti-Id mAb could regulate antibody response directed against a selected epitope recognized by 1-5 mAb, and the induction of collagen-induced arthritis in DBA/1J mice. DBA/1J mice intravenously preinjected with anti-Id mAb to 1-5, did not produce anti-CII antibody expressing 1-5 Id upon immunization with human CII. Furthermore, as the development of collagen-induced arthritis (CIA) in DBA/1J mice pretreated with anti-Id mAb to 1-5 was significantly suppressed, anti-Id mAb will be a useful tool for studying the regulation of antibody response to a selected epitope. This study lends support to our hypothesis that the 1-5 epitope is an arthritogenic epitope. |
